Hereditary optic neuropathies

Medical Management of Hereditary Optic Neuropathies

Hereditary optic neuropathies are diseases affecting the optic nerve. The most common are mitochondrial hereditary optic neuropathies, i.e., the maternally inherited Leber's hereditary optic neuropathy (LHON) and dominant optic atrophy (DOA). They both share a mitochondrial pathogenesis that leads to the selective loss of retinal ganglion cells and axons, in particular of the papillo-macular bu...

Oxydative Metabolism in Optic Nerve Myelin: New Perspectives in Hereditary Optic Neuropathies

ANT Adenosine Nucleotide Translocase; BSA Bovine Serum Albumin; CLSM Confocal Laser Scanning Microscopy; CNS Central Nervous System; EGTA Ethylene Glycol Tetraacetic Acid; ETC Electron Transport Chain; GA Glutaraldehyde; Ide, Idebenone; IM Isolated Myelin; MBP Myelin Basic Protein; LHON LeberHereditary Optic Neuropathy; MW MolecularWeight; NS Nervous System; OXPHOS Oxidative Phosphorylation; PB...

Mitochondrial optic neuropathies.

AutoiMMune/inflAMMAtory optic neuropAthies

InTRoDUCTIon Inflammatory, demyelinating optic neuritis is one of the most common optic neuropathies in young adults. It occurs idiopathically, or in association with multiple sclerosis, and follows a typical course of progressing visual dysfunction often with pain for one – two weeks, followed by significant resolution over the next few weeks. Due to the characteristic presentation and frequen...

The toxic optic neuropathies.

As is common knowledge, there is an argument as to whether or not the toxic radical cyanide is an important aetiological agent responsible for the development of some of the conditions grouped under the term toxic amblyopia. There are arguments and counterarguments, and it would appear useful at this stage to state the evidence for and against cyanide as a cause of these conditions. The argumen...